SrasV1, Main, Exploration, bibRecord, 003C75

Tertiary structure prediction of SARS coronavirus helicase.

Identifieur interne : 003C75 ( Main/Exploration ); précédent : 003C74; suivant : 003C76

Tertiary structure prediction of SARS coronavirus helicase.

Auteurs : Andrea Bernini [Italie] ; Ottavia Spiga ; Vincenzo Venditti ; Filippo Prischi ; Luisa Bracci ; Jiandong Huang ; Julian A. Tanner ; Neri Niccolai

Source :

Biochemical and biophysical research communications [ 0006-291X ] ; 2006.

RBID : pubmed:16579970

Descripteurs français

KwdFr :
- Analyse de séquence de protéine, Helicase (), Modèles moléculaires, Protéines virales (), Simulation numérique, Sites de fixation, Structure tertiaire des protéines, Virus du SRAS (enzymologie).
MESH :
- enzymologie : Virus du SRAS.
- Analyse de séquence de protéine, Helicase, Modèles moléculaires, Protéines virales, Simulation numérique, Sites de fixation, Structure tertiaire des protéines.

English descriptors

KwdEn :
- Binding Sites, Computer Simulation, DNA Helicases (chemistry), Models, Molecular, Protein Structure, Tertiary, SARS Virus (enzymology), Sequence Analysis, Protein, Viral Proteins (chemistry).
MESH :
- chemical , chemistry : DNA Helicases, Viral Proteins.
- enzymology : SARS Virus.
- Binding Sites, Computer Simulation, Models, Molecular, Protein Structure, Tertiary, Sequence Analysis, Protein.

Abstract

SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors.

DOI: 10.1016/j.bbrc.2006.03.069
PubMed: 16579970

Affiliations:

Italie

Le document en format XML

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<term>SARS Virus (enzymology)</term>
<term>Sequence Analysis, Protein</term>
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<term>Modèles moléculaires</term>
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<term>Simulation numérique</term>
<term>Sites de fixation</term>
<term>Structure tertiaire des protéines</term>
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<term>Protéines virales</term>
<term>Simulation numérique</term>
<term>Sites de fixation</term>
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<front><div type="abstract" xml:lang="en">SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors.</div>
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Serveur d'exploration SRAS

Tertiary structure prediction of SARS coronavirus helicase.

Tertiary structure prediction of SARS coronavirus helicase.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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